diff -urN pypy2.7-v7.3.8-src.orig/lib_pypy/_cffi_ssl/_cffi_src/openssl/ssl.py pypy2.7-v7.3.8-src/lib_pypy/_cffi_ssl/_cffi_src/openssl/ssl.py
--- pypy2.7-v7.3.8-src.orig/lib_pypy/_cffi_ssl/_cffi_src/openssl/ssl.py	2022-03-27 20:40:31.151380366 +0200
+++ pypy2.7-v7.3.8-src/lib_pypy/_cffi_ssl/_cffi_src/openssl/ssl.py	2022-03-27 20:45:26.044401605 +0200
@@ -739,7 +739,7 @@
 int (*SSL_get_min_proto_version)(SSL *ssl) = NULL;
 int (*SSL_get_max_proto_version)(SSL *ssl) = NULL;
 #endif
-#if CRYPTOGRAPHY_OPENSSL_LESS_THAN_110
+#if CRYPTOGRAPHY_OPENSSL_LESS_THAN_110 && !CRYPTOGRAPHY_IS_LIBRESSL
 int (*SSL_CTX_set_min_proto_version)(SSL_CTX *ctx, int version) = NULL;
 int (*SSL_CTX_set_max_proto_version)(SSL_CTX *ctx, int version) = NULL;
 int (*SSL_set_min_proto_version)(SSL *ssl, int version) = NULL;